Business Engagement & Technology Principal Analyst

Role Summary: Vertex is seeking a Principal Business Analyst, Cell & Gene Therapy Commercial Technology to join the Data, Technology and Engineering (DTE) team and play a key role in shaping and supporting technology solutions for our Cell & Gene Therapy commercial organization. This individual will partner closely with commercial stakeholders and technology teams to define business needs, improve processes, and enable scalable digital capabilities that support scaling operations, order management, analytics, and end to end patient journey across multiple platforms and technologies. The ideal candidate will bring strong business analysis expertise, deep stakeholder management skills, experience delivering AI and automation and supporting commercial functions within biotechnology, pharmaceuticals, or other regulated industries. This role requires a blend of strategic thinking, process optimization, and hands-on delivery support to ensure technology solutions align with business priorities and compliance expectations. Work ModelHybrid or on-site

Key Responsibilities: Partner with Commercial, Cell & Gene Therapy, and Technology stakeholders to understand business strategies, priorities, and operational challenges Lead requirements gathering, business process analysis, and solution design for complex commercial technology initiatives Translate business needs into detailed functional requirements, user stories, process maps, business rules, and solution recommendations Support technology initiatives across key commercial domains such as patient services, order management, field enablement, commercial analytics, and data integration - Partner with business and technical teams to help define and deliver AI and automation use cases aligned to business priorities Analyze current-state and future-state business processes to identify opportunities for standardization, automation, and optimization Facilitate cross-functional workshops and working sessions to align stakeholders on priorities, requirements, and solution outcomes Collaborate with product managers, architects, developers, data teams, and vendors to ensure solutions meet business objectives and enterprise standards Drive business readiness activities including testing support, user acceptance testing, training coordination, adoption planning, and change management Ensure solutions align with relevant compliance, privacy, legal, promotional review, and regulated industry requirements Develop and maintain high-quality documentation including business requirements, process flows, use cases, impact assessments, and traceability artifacts Use data, metrics, and stakeholder feedback to evaluate solution effectiveness and support continuous improvement Contribute to business analysis best practices across the commercial technology organization

Required Qualifications: Bachelor’s degree in Business, Information Systems, Life Sciences, Engineering, or a related field Significant experience in business analysis, product delivery, process improvement, or related roles within biotechnology, pharmaceuticals, healthcare, or another regulated industry Experience supporting commercial business functions and technology platforms, preferably in life sciences Demonstrated ability to lead complex, cross-functional initiatives involving multiple business and technical stakeholders Strong experience eliciting, documenting, validating, and managing business and functional requirements Proven ability to analyze and improve business processes and translate them into technology-enabled solutions - Experience supporting or contributing to automation, advanced analytics, AI-enabled, or digital transformation initiatives Experience working across the system or product delivery lifecycle, including planning, requirements, testing, implementation, and post-go-live support Excellent communication, facilitation, presentation, and stakeholder management skills Strong analytical, problem-solving, and organizational abilities Understanding of compliance and documentation expectations in regulated business environments Technical Skills RequiredBusiness and functional requirements documentation Process mapping and business workflow analysis User story creation and backlog refinement Gap analysis and solution assessment Data analysis, reporting, and dashboard requirements support Stakeholder workshop facilitation User acceptance testing support and test scenario development Change management and training support Familiarity with CRM and commercial technology ecosystems - Understanding of AI-enabled business solutions, workflow automation, and process digitization concepts Knowledge of Agile, Waterfall, or hybrid project delivery methodologies Proficiency with tools such as Jira, Confluence, Visio, Microsoft Excel, PowerPoint, Word, and other collaboration platforms Understanding of enterprise data flows, integrations, and commercial reporting environments

Preferred Skills: Experience supporting Cell & Gene Therapy commercial business models and technology capabilities, including Salesforce and AI Knowledge of pharmaceutical or biotech commercial operations, including field engagement, market access, patient support, and launch planning Experience with platforms such as CRM systems, data visualization tools, customer engagement platforms, and commercial analytics solutions - Experience with AI use case definition, intelligent automation, workflow tools, or emerging digital technologies in support of business operations Familiarity with patient services, specialty distribution, HUB operations, and reimbursement-related workflows Experience with digital transformation, automation, and master data or system integration initiatives Understanding of privacy, promotional, legal, and compliance considerations in commercial technology Relevant certifications such as CBAP, PMI-PBA, Agile, Scrum, or Lean Six Sigma Advanced degree in Business, Information Systems, Life Sciences, or a related discipline Pay RangePay Range: $164,400 - $246,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

Benefits: From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex DesignationHybrid-Eligible Or On-Site Eligible Flex Eligibility StatusIn this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or 2. On-Site: work five days per week on-site with ad-hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. Company InformationVertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com. Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency. Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston’s Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry’s top places to work, including 14 consecutive years on Science magazine’s Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X, LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.