Principal Clinical Scientist

About the Role: What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI understands and reasons about medical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to frontier AI research - ensuring the clinical data and analyses powering next-generation AI systems meet the same exacting standards expected in real-world regulatory submissions. This is a fully remote, flexible contract role built for experienced clinical scientists who want to contribute to something genuinely new. No AI background required - just deep command of clinical research and a sharp eye for scientific quality. OrganizationAlignerr TypeHourly Contract LocationRemote Commitment10-40 hours/week What You'll DoDesign and critically review clinical trial protocols used to generate high-quality, regulatory-grade datasets for AI training Interpret and audit clinical trial results for accuracy, consistency, and alignment with regulatory expectations Evaluate AI-generated clinical analyses for scientific soundness and methodological integrity Provide structured expert feedback that directly improves how AI models reason about clinical evidence, outcomes, and trial data Work independently and asynchronously - fully on your own schedule Who You AreSenior-level experience designing clinical trial protocols intended for regulatory submission Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent global bodies Strong grounding in clinical research methodology, biostatistics, or translational science Naturally detail-oriented with a rigorous, systematic approach to evaluating scientific quality Clear and precise written communicator - able to document findings and feedback with authority No prior AI or tech experience required Nice to HavePrior involvement in data annotation, data quality assurance, or evaluation systems Experience reviewing or contributing to clinical evidence packages for drug, device, or diagnostic submissions Background spanning multiple therapeutic areas or trial phases Familiarity with AI-generated content or model evaluation workflows Why Join UsWork directly on frontier AI systems with real impact on clinical and biomedical research Fully remote and flexible - work when and where it suits you Freelance autonomy with the structure of meaningful, expert-level work Influence how AI understands, evaluates, and communicates real-world clinical evidence Potential for ongoing work and contract extension as new projects launch