Topos Bio At Topos Bio, we're pioneering drug discovery for intrinsically disordered proteins—targets that have eluded conventional approaches in neurodegeneration, oncology, and cardiometabolic disease. We're seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts. You'll work at the interface of disease biology, protein biophysics, and drug screening.
What you will do: Develop and optimize mammalian cell-based assays for disordered protein targets Execute phenotypic and reporter-based screening campaigns to validate computational hits Characterize compound activity and support structure-activity relationship studies Collaborate with computational scientists to integrate experimental data with modeling workflows Establish robust assay protocols and quality control metrics
What we are looking for: Strong foundation in mammalian cell culture and cellular assay development Experience with disease-relevant cellular models Ability to troubleshoot complex biological systems and optimize experimental protocols Track record of productivity and effective collaboration Preferred PhD in cell and molecular biology with focus on disease models Industry experience in drug discovery or biotech Experience with reporter assays and high-throughput screening platforms Familiarity with oncology, neurodegeneration, or metabolic disease models Track record of developing novel cellular assays or screening approaches

Also on the board Same function, level within a rung

Level

Senior

Location

South San Francisco, CA

Occupation

Molecular and Cellular Biologists

Industry

Research and Development in Biotechnology (except Nanobiotechnology)

Posted

yesterday

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