Principal Scientist - In Vivo Pharmacology

The Position: The Principal Scientist will be responsible for strategy implementation and operations for conducting and summarizing non‑clinical in vivo studies internally and externally in the support of new drug evaluations. Design, coordinate, and report pre‑clinical pharmacokinetic and pharmacodynamic in vivo experiments within research projects as part of target validation, target maturation, or mode‑of‑action studies. Develop and improve in vivo models supporting non‑clinical studies, take an active role in research projects, and contribute to innovation by identifying and exploring new therapeutic targets and principles. Communicate evaluations and implications of in vivo data internally, externally, and in regulatory submissions as relevant. Proven subject matter expertise. Manages field of expertise that requires highly specialized knowledge of strategic importance to the SVP area. Recognized as an expert in own area within the organization and perceived as expert within one or several key processes across an SVP area. Requires specialized depth and/or breadth of expertise. Interprets internal or external business issues and solutions. Recommends solutions/best practices. Solves complex problems; takes a broad perspective to identify. May require strong pharmaceutical industry knowledge and understanding. Acts as mentor for senior colleagues within field of expertise. In‑depth understanding of subject matter & relationship to other key areas related to drug development; expert‑level guidance for project team related to experimental strategies to evaluate emerging targets or technologies; propose & oversee external collaborations & strategic partnerships to further company goals related to therapeutic or technology area; clear understanding of link between scientific project goals & overall/long‑term business needs. May mentor or directly supervise less experienced team members based on business need, skill, and/or interest. Relationships Reports to the head of the relevant department at Novo Nordisk. Internal relationships include working closely with technical staff & other members of the scientific leadership team; regular collaborations with members of other research departments at Novo Nordisk; & frequent interaction with project managers & other colleagues across global R&D. Individual may direct the work of other staff members. Individual will interact with external research collaborators both academia‑ & industry‑based.

Essential Functions: Conduct and summarize non‑clinical in vivo studies:

• Implement strategies and operations for conducting and summarizing non‑clinical in vivo studies
• Ensure the proper execution of in vivo experiments internally and externally
• Analyze and interpret data from in vivo studies to provide insights and recommendations for new drug evaluations
• Collaborate with cross‑functional teams to support the development and implementation of in vivo study protocols
• Design and coordinate pre‑clinical pharmacokinetic and pharmacodynamic experiments:
• Develop experimental designs for pre‑clinical pharmacokinetic and pharmacodynamic studies
• Coordinate the execution of in vivo experiments, including dosing, sample collection, and data analysis
• Monitor and evaluate the performance of in vivo experiments to ensure data quality and integrity
• Collaborate with internal and external partners to optimize study design and execution
• Develop and improve in vivo models supporting non‑clinical studies:
• Identify and evaluate new in vivo models to support non‑clinical studies
• Contribute to the development and validation of in vivo models for target validation, target maturation, and mode‑of‑action studies
• Stay updated on the latest advancements in in vivo pharmacology and biology to drive innovation and improvement in study models
• Collaborate with cross‑functional teams to implement improvements in in vivo models and study protocols