Scientist I - ML/AI Foundational Models for Synthetic Enhancer Design

Are you ready for new challenges and new opportunities? Join our team in Seattle! Current job opportunities are posted here as they become available. Scientist I - ML/AI Foundational Models for Synthetic Enhancer Design TheAllen Instituteaccelerates science for a healthier world through large-scale research designed to answer some of the most complex questions in biology. Our multi-disciplinary teams generate foundational knowledge, tools, and data to understand how our brain, cells, and immune system work. We share our work openly so others can build on it, move faster, and ask bigger questions. We drive discovery forward and create new possibilities for improving human health. Brain Healthis a new global collaborative research initiative designed to accelerate understanding of human brain diseases through large-scale human tissue analysis, open science, AI-enabled disease modeling, and translational platform technologies. Building on foundational advances in human brain cell atlases, quantitative neuropathology, single-cell and spatial biology, multimodal molecular profiling, and AI-enabled analysis, Brain Health is developing a scalable framework for understanding disease progression directly in the human brain and identifying new opportunities for therapeutic development. We seek aScientist Ito build the computational backbone of a lab-in-the-loop platform that designs and validates synthetic enhancers for precision cell-type targeting in the brain. In this cycle, model-designed sequences are tested experimentally, and the results retrain the next round of models. You will contribute to an open-source codebase for training, fine-tuning, evaluating, and running inference on genomic sequence-to-function models. You will scale training across our cloud GPU infrastructure, turn large-scale cross-species whole-brain multi-omic data into reproducible training sets, and build on the thousands of enhancer-AAV vectors already screened and released publicly through the Allen Institute Genetic Tools Atlas to inform the design of novel synthetic enhancers. The ideal candidate is a strong scientific software engineer and ML practitioner excited to share their models, sequences, and code as community tools for exploring regulatory genomics and designing enhancers in any tissue. At the Allen Institute, we believe that science is for everyone – and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions.

Ph. D. in computer science, computational biology, bioinformatics, applied mathematics, engineering, or a related field; or an equivalent combination of degree and experience Strong software engineering practice in Python, including version control, testing, code review, dependency management, and reproducible environments Experience training deep learning models in PyTorch, JAX, or TensorFlow on multi-GPU or distributed infrastructure Experience building data pipelines for large scientific datasets that do not fit in memory